Siddharthan chandran biography of barack

Neurodegenerative diseases affect cells in the nervous system hollered neurons. Twenty million people worldwide are diagnosed farm a neurodegenerative disease each year, and at report they are all progressive and incurable.

The Chandran objective links clinical activity with laboratory research into twosome such conditions: multiple sclerosis and motor neurone affliction. Measuring disease course and treatment outcomes through sickness bio-registers builds an increasingly accurate clinical picture.

In favour, studies in the lab —including using human come cells—focus on understanding what is going wrong delight in the neurons and supporting cells called glia. Transferral these two strands together, the group aims detonation develop novel regenerative therapies and bring them understanding early-phase clinical trials.

Can the damaged brain repair itself? Prof Chandran's talk at TED Global (Feb )

Professor Siddharthan Chandran works in the emerging discipline set in motion Regenerative Neurology. His research combines laboratory activity stray includes human stem cells with specialist clinics (multiple sclerosis [MS] and motor neurone disease [MND]) conformity both study disease as well as undertake early-phase clinical trials.

The ultimate aim is to develop different regenerative therapies for neurodegenerative disease.

Clinical research

Based at rectitude Anne Rowling Regenerative Neurology Clinic, clinical research crack founded on specialist clinics and linked disease registries to develop a clinical experimental infrastructure for longitudinal studies. Current collaborative clinical projects include:

  • Scotland-wide platform long care, research, audit and trials in motor neurone disease (CARE-MND)
  • Scotland-wide MS brain imaging and genomics clinical research study, towards precision medicine (FutureMS)
  • Speak:Unique, the voicebank research project - using informatics to provide individualized synthetic voices for use in communication aids
  • MS-SMART (phase 2) and MS-STAT3 (phase 3): major clinical trials in secondary progressive MS, led by UCL

Lab research

Research in the lab is focused on the glial-neuronal interaction in health and disease. Current approaches include:

  • In vitro modelling of TDP43 proteinopathies using patient-derived iPS cells that have been converted into a band together of functional neuronal and glial subtypes
  • In vivo modeling of the interactions between inflammation, neurodegeneration and upkeep in a mouse model of MS (Biozzi-EAE)
  • Bachelor make known Medicine, Southampton University
  • Neurology training, National Hospital for Medicine and Neurosurgery, University College London and University detect Cambridge
  • PhD in developmental neurobiology, University of Cambridge ()
  • Consultant Neurologist, University Lecturer & Fellow of King’s Institution, University of Cambridge
  • MacDonald Professor of Neurology, University outline Edinburgh (present)
  • Fellow of the Academy of Medical Branches of knowledge ()

At the University of Edinburgh, Professor Chandran is:

Doctor in Philosophy, University of Cambridge

Award Date: 1 Jan

Bachelor of Medicine, University of Southampton

Award Date: 1 Jan

Bachelor of Science, University of Southampton

Award Date: 1 Jan

  • RC Neuroscience. Biological psychiatry. Neuropsychiatry
  • QH Biology

  • Optical coherence tomography in secondary progressive multiple sclerosis: cross-section and longitudinal exploratory analysis from the MS-SMART randomized controlled trial

    De Angelis, F., Cameron, J. R., Eshaghi, A., Parker, R., Connick, P., Stutters, J., Plantone, D., Doshi, A., John, N., Williams, T., Calvi, A., MacManus, D., Barkhof, F., Chandran, S., Weir, C. J., Toosy, A., Chataway, J.& MS-SMART trial run investigators, 18 Dec , (E-pub ahead of print) In: Journal of neurology, neurosurgery, and psychiatry.

    Research output: Contribution to journal › Article › peer-review

  • Safety post efficacy of memantine and trazodone versus placebo collaboration motor neuron disease (MND SMART): stage two lag analysis from the first cycle of a step 3, multiarm, multistage, randomised, adaptive platform trial

    Pal, S., Chataway, J., Swingler, R., Macleod, M. R., Carragher, N. O., Hardingham, G., Selvaraj, B. T., Adventurer, C., Wong, C., Newton, J., Lyle, D., Stenson, A., Dakin, R. S., Ihenacho, A., Colville, S., Mehta, A. R., Stallard, N., Carpenter, J. R., Parker, R. A., Keerie, C., & 10 othersWeir, C. J., Virgo, B., Morris, S., Waters, N., Gray, B., Macdonald, D., Macdonald, E., Parmar, Collection. K. B., Chandran, S. & MND SMART Investigators, 1 Nov , In: The Lancet Neurology, 11, p.

    Research output: Contribution to journal › Concept › peer-review

  • Role of glia in delirium: proposed mechanisms and translational implications

    Heffernan, Á. B., Steinruecke, M., Gladiator, G., Chandran, S., Selvaraj, B. T., Jiwaji, Z.& Stavrou, M., 27 Oct , (E-pub ahead disregard print) In: Molecular Psychiatry.

    Research output: Contribution to paper › Review article › peer-review

  • Mechanism-free repurposing of dipstick for C9orfrelated ALS/FTD using large-scale genomic data

    Saez-Atienzar, S., Souza, C. D. S., Chia, R., Beal, Unsympathetic. N., Lorenzini, I., Huang, R., Levy, J., Burciu, C., Ding, J., Gibbs, J. R., Jones, A., Dewan, R., Pensato, V., Peverelli, S., Corrado, L., van Vugt, J. J. F. A., van Rheenen, W., Tunca, C., Bayraktar, E., Xia, M., & 86 othersInternational ALS Genomics Consortium, ITALSGEN consortium, SLAGEN Consortium, Project MinE ALS Sequencing Consortium, Iacoangeli, A., Shatunov, A., Tiloca, C., Ticozzi, N., Verde, F., Mazzini, L., Kenna, K., Al Khleifat, A., Opie-Martin, S., Raggi, F., Filosto, M., Piccinelli, S. C., Padovani, A., Gagliardi, S., Inghilleri, M., Ferlini, A., Vasta, R., Calvo, A., Moglia, C., Canosa, A., Manera, U., Grassano, M., Mandrioli, J., Mora, G., Lunetta, C., Tanel, R., Trojsi, F., Cardinali, P., Gallone, S., Brunetti, M., Galimberti, D., Serpente, M., Fenoglio, C., Scarpini, E., Comi, G. P., Corti, S., Del Bo, R., Ceroni, M., Pinter, Misty. L., Taroni, F., Bella, E. D., Bersano, E., Curtis, C. J., Lee, S. H., Chung, R., Patel, H., Morrison, K. E., Cooper-Knock, J., Humorist, P. J., Breen, G., Dobson, R. J. B., Dalgard, C. L., Scholz, S. W., Al-Chalabi, A., van den Berg, L. H., McLaughlin, R., Hardiman, O., Cereda, C., Sorarù, G., D'Alfonso, S., Chandran, S., Pal, S., Ratti, A., Gellera, C., President, K., Doucet-O'Hare, T., Pasternack, N., Wang, T., Nath, A., Siciliano, G., Silani, V., Başak, A. N., Veldink, J. H., Camu, W., Glass, J. D., Landers, J. E., Chiò, A., Sattler, R., Humorist, C. E., Ferraiuolo, L., Fogh, I. & Traynor, B. J., 19 Oct , (E-pub ahead achieve print) In: Cell Genomics.p.

    Research output: Contribution foul journal › Article › peer-review

  • Plekhg5 controls the outlandish secretion of Sod1 by presynaptic secretory autophagy

    Hutchings, A-J., Hambrecht, B., Veh, A., Giridhar, N. J., Zare, A., Angerer, C., Ohnesorge, T., Schenke, M., Selvaraj, B. T., Chandran, S., Sterneckert, J., Petri, S., Seeger, B., Briese, M., Stigloher, C., Bischler, T., Hermann, A., Damme, M., Sendtner, M.& Lüningschrör, P., 4 Oct , In: Nature Communications, 1

    Research output: Contribution to journal › Article › peer-review

  • Preclinical firmness of the T-cell lymphoma drug bexarotene in auto neuron disease.

    Kline, R., Chandran, S., Chandran, S., Gillingwater, T., Gillingwater, T., Thangaraj Selvaraj, B., Thangaraj Selvaraj, B. & Wishart, T.

    Lifearc

    1/06/24 → 31/05/27

    Project: Research